Game Over starts with a serial killer (whose face is not revealed) stalking a girl with cancer from outside her house and later at midnight killing her by wrapping her head in plastic and tying her hands behind her. After that he takes her to an abandoned field where he beheads her and sets her body on fire.Later, the film focuses on Swapna (Taapsee Pannu) who is a single young woman and also a talented game designer. She has a fear of the darkness, and also suffers from post-traumatic stress more so known as 'anniversary reaction', a condition, which triggers unsettling feelings around the anniversary of a traumatic event. For Swapna, it is the horrific memory of her rape that took place on last New Year's Eve.It's her second time that she suffers from the uncontrollable feeling whenever she enters darkness; the first time was one year ago, the following days after she was raped. Her symptom starts when she feels pain at her wrist, where there is a tattoo she got one year ago. As she got the tattoo too long ago, it was explained technically impossible by a doctor that the pain was caused by it, but only she knows there's connection between the tattoo and her miserable memory. Her family have a traditional mind that think decent girls shouldn't have tattoo or go out in the night; she didn't listen, and was later raped. Instead of encouraging her afterward, her parents kept blaming the tragedy on her, for having a tattoo and going out in the night.Because of this, she leaves her parents, never contacted them since, and leads a secluded life with Kalamma (Vinodhini Vaidyanathan), a housemaid who stays with her. Her only solace is her love for gaming. Swapna later learns that her tattoo ink was mixed with a stranger's ash, because of a mistake by the tattoo artist. She begins to have some bizarre dreams and finds that the girl Amutha (Sanchana Natarajan), a cancer survivor, was an unfortunate victim of a serial killer. Amutha's mother tells Swapna that her daughter wilWatch drama online for free.